1025436-07-0

Basic information

• Product Name: C₂₂H₁₆ClN₅O₈
• CAS NO: 1025436-07-0
• Molecular Weight: 513.851
• Mol File: 1025436-07-0.mol

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₆ClN₅O₈(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₆ClN₅O₈(1025436-07-0)
• EPA Substance Registry System: C₂₂H₁₆ClN₅O₈(1025436-07-0)

Safety Data

• Hazardous Substances Data: 1025436-07-0(Hazardous Substances Data)

Upstream product

• 1025435-98-6 C₂₇H₂₆ClN₅O₈ 

Relevant articles and documents

Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: Synthesis and structure-activity relationships

This paper reports the synthesis and AMPA, Gly/NMDA, and KA receptor binding affinities of a new set of 1,9-disubstituted-8-chloro-pyrazolo[1,5-c]quinazoline-2-carboxylates 2-34. Binding data show that, in general, compounds 2-34 bind to the AMPA receptor with good affinity and selectivity. In particular, the obtained results indicate that the contemporary presence of a 1,2-dicarboxylic acid moiety and suitable benzo-substituents on the PQZ system is important to gain selective AMPA receptor antagonists. Moreover, this study shows that the presence of a 2-carboxybenzoylamino substituent at position-9 (compounds 33-34) is important for obtaining selective KA receptor antagonists. Some selected compounds were also tested for their functional antagonistic activity at both AMPA and NMDA receptor-ion channels.