1025436-33-2Relevant academic research and scientific papers
Total synthesis and determination of relative and absolute configuration of multiplolide A
Ramana,Khaladkar, Tushar P.,Chatterjee, Soumitra,Gurjar, Mukund K.
, p. 3817 - 3822 (2008/09/19)
(Chemical Equation Presented) A flexible approach for total syntheses of possible multiplolide A diastereomers establishing the relative and absolute configuration is documented. The adopted strategy features ring-closing metathesis (RCM) as the key reaction and screening of a set of substrates for the feasibility of RCM in general and for the requisite E-configuration of ring olefin in particular. Selective protecting groups manipulation prior to the assembly of the central macrocyclic core was instrumental in installing the epoxide functionality on a fully deprotected nonenolide at the end of the synthesis.
