1025448-69-4Relevant academic research and scientific papers
Synthesis and biological evaluation of pyrroloiminoquinone derivatives
Passarella, Daniele,Belinghieri, Francesca,Scarpellini, Michele,Pratesi, Graziella,Zunino, Franco,Gia, Ornella Maria,Via, Lisa Dalla,Santoro, Giuseppe,Danieli, Bruno
, p. 2431 - 2438 (2008/09/21)
Synthesis of 10 pyrroloiminoquinone derivatives is presented. The strategy is based around the elaboration of a common intermediate by reaction with primary amines. All the compounds obtained have been subjected to antiproliferative activity with three different cell lines (NCI-H460, HeLa, and HL-60). The capacity of 4 selected compounds to affect the enzymatic activity of the nuclear enzyme DNA topoisomerase II and to form the typical DNA fragmentation which occurs in the apoptotic process is discussed here.
