1025468-52-3

Upstream product

• 1025468-50-1 (1S)-1-(4-fluorophenyl)-3-[(2S,3R)-2-(4-iodophenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]propyl acetate 
• 102573-87-5 2-ethynyl-2-hydroxypropane-1,3-diyl diacetate 

Downstream Products

• 1025468-38-5 (1S)-3-{(2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-4-oxo-1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]azetidin-3-yl}-1-(4-fluorophenyl)propyl acetate 
• 1025468-55-6 (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-4-oxo-1-{4-[(trimethylsilyl)ethynyl]phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate 
• 1025468-53-4 (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-4-oxo-1-{4-[3-(1H-1,2,4-triazol-1-yl)prop-1-yn-1yl]-phenyl}azetidin-3-yl)-1-(4-fluorophenyl)propyl acetate 
• 1039433-80-1 (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-1-{4-[6-(methylsulfonyl)hex-1-yn-1-yl]phenyl}-4-oxoazetidin-3-yl)-1-(4-fluorophenyl)propyl acetate 
• 1039433-82-3 (1S)-3-[(2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybutyl}phenyl)-4-oxo-1-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)azetidin-3-yl]-1-(4-fluorophenyl)propyl acetate 
• 1039433-76-5 (1S)-3-((2S,3R)-2-(4-{4-(acetyloxy)-3-[(acetyloxy)methyl]-3-hydroxybut-1-yn-1-yl}phenyl)-1-{4-[4-(methylsulfonyl)but-1-yn-1-yl]phenyl}-4-oxoazetidin-3-yl)-1-(4-fluorophenyl)propyl acetate 

Relevant academic research and scientific papers

HETEROCYCLYL-SUBSTITUTED ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS

This invention provides cholesterol absorption inhibitors of Formula I: and the pharmaceutically acceptable salts thereof, wherein R12 is a hydroxylated alkyl group and R9 contains a heterocyclic ring. The compounds are useful for lowering plasma cholesterol levels, particularly LDL cholesterol, and for treating atherosclerosis and preventing atherosclerotic disease events.