10256-77-6

Basic information

• Product Name: N-[3-(Dimethylamino)propyl]-4-methylbenzene-1-sulfonamide
• Synonyms: N-[3-(Dimethylamino)propyl]-4-methylbenzene-1-sulfonamide;N-[3-(Dimethylamino)propyl]-4-methylbenzenesulfonamide
• CAS NO: 10256-77-6
• Molecular Formula: C12H20 N2 O2 S
• Molecular Weight: 256.3644
• Mol File: 10256-77-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 373°Cat760mmHg
• Flash Point: 179.4°C
• Appearance: /
• Density: 1.116g/cm³
• Vapor Pressure: 9.25E-06mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: N-[3-(Dimethylamino)propyl]-4-methylbenzene-1-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(Dimethylamino)propyl]-4-methylbenzene-1-sulfonamide(10256-77-6)
• EPA Substance Registry System: N-[3-(Dimethylamino)propyl]-4-methylbenzene-1-sulfonamide(10256-77-6)

Safety Data

• Hazardous Substances Data: 10256-77-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H20N2O2S/c1-11-5-7-12(8-6-11)17(15,16)13-9-4-10-14(2)3/h5-8,13H,4,9-10H2,1-3H3

Upstream product

• 109-55-7 1-amino-3-(dimethylamino)propane 
• 98-59-9 p-toluenesulfonyl chloride 
• 97640-46-5 levopimaradien-18-ol 
• 640-42-6 neoabietadien-18-ol 

Relevant articles and documents

Flow synthesis and biological activity of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors

A series of secondary and tertiary aryl sulfonamides were synthesized under flow conditions and evaluated for their ability to selectively inhibit tumor-associated carbonic anhydrase isoforms IX and XII. The tested compounds revealed to be highly potent CA IX inhibitors in nanomolar range, and to inhibit CA XII activity with different ranks of potencies. Remarkably, 4-methyl-N-phenyl-benzenesulfonamide was a selective nanomolar CA IX inhibitor with an IC50 of 90 nM.

PREPARATION OF SULFONAMIDE-CONTAINING ANTIMICROBIALS AND SUBSTRATE TREATING COMPOSITIONS OF SULFONAMIDE-CONTAINING ANTIMICROBIALS

A quaternary ammonium sulfonamide compound of formula (I): wherein R = (II), C1-C3 linear or branched alkyl, R1 and R2 are the same or different and selected from C1 to C18 linear or branched alkyl, R3 and R4 are the same or different and selected from C1 to C4 linear or branched alkyl, CF3, OR5 where R5 is C1 to C8 linear or branched alkyl or polyethylene oxide, l is 1, 2, 3, 4, 5, 6, 7 or 8, m is 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17, n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17 or 18, wherein the aryl groups of R may be substituted or unsubstituted, X = halogen, and Y = (III) wherein R6, R7, R8, R9 and R10 are the same or different and selected from C1 to C6 linear or branched alkyl and the benzophenone is selected from the group consisting of substituted benzophenone and unsubstituted benzophenone, processes for preparing the compound and antimicrobial surface coating compositions of the compound.

Synthesis and characterization of abietadiene, levopimaradiene, palustradiene, and neoabietadiene: Hydrocarbon precursors of the abietane diterpene resin acids

The abietane diterpenes - abietadiene, levopimaradiene, palustradiene, and neoabietadiene (1b-4b) - were prepared from the corresponding resin acids by diazomethane esterifications, LiAlH4 reductions, tosylations, and Zn/NaI reductions. Abietadiene was also obtained less efficiently by catechol borane reduction of abietadienal tosylhydrazone and Li/NH3 reduction of its 18-phenylthio derivative. These conjugated dienes were characterized by chromatographic properties (HPLC, TLC, GC), MS fragmentation patterns, optical rotations, and UV, IR, 1H NMR, and 13C NMR data. Assignments for the 1H and 13C NMR spectra were made by COSY, DEPT, HMQC, HMBC, NOE data, H-H coupling analysis, and comparisons with literature data. The four diterpenes were identified as cyclization products of recombinant abietadiene synthase, supporting their likely role in the biosynthesis of the abietane resin acids in conifer oleoresin.