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Usage

Uses

Used in Leprosy Treatment:
Benzenamine, 4,4'-(2,5-pyrimidinediyl)bisis used as an antimicrobial agent for the treatment of leprosy, a chronic infectious disease caused by Mycobacterium leprae. It inhibits bacterial dihydropteroate synthase, preventing the synthesis of dihydrofolic acid, which is crucial for the bacteria's survival and replication.
Used in Dermatological Applications:
Benzenamine, 4,4'-(2,5-pyrimidinediyl)bisis used as an anti-inflammatory agent in various dermatological conditions, such as dermatitis herpetiformis, bullous pemphigoid, and pyoderma gangrenosum. Its anti-inflammatory properties help reduce inflammation, itching, and skin lesions associated with these conditions.
Used in Antiprotozoal Therapy:
Benzenamine, 4,4'-(2,5-pyrimidinediyl)bisis used as an antiprotozoal agent for the treatment of certain parasitic infections, such as leishmaniasis. Its antimicrobial properties help control the growth and replication of the protozoan parasites, alleviating the symptoms and complications associated with these infections.
Used in Inflammatory Disease Management:
Benzenamine, 4,4'-(2,5-pyrimidinediyl)bisis used as an anti-inflammatory agent in the management of various inflammatory diseases, such as rheumatoid arthritis and lupus. Its ability to modulate immune cell function and inhibit inflammatory pathways helps reduce inflammation and alleviate symptoms in these conditions.

Upstream product

• 80460-73-7 (4-aminophenyl)boronic acid hydrochloride 
• 32779-37-6 2,5-dibromopyrimidine 
• 32779-36-5 5-Bromo-2-chloropyrimidine 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 24067-17-2 4-nitrophenylboronic acid 

Relevant academic research and scientific papers

CATALYTIC HYDROGENATION OF 2,5-bis(p-NITROPHENYL)PYRIMIDINE

We have studied the catalytic hydrogenation of 2,5-bis(p-nitrophenyl)pyrimidine over palladium on carbon under different conditions.We have established that hydrogenation in acetic acid at atmospheric hydrogen pressure leads to formation of 2,5-bis(p-amin

Nitrogenous aromatic heterocyclic nitro compound as well as preparation method and application thereof

The invention provides a nitrogen-containing aromatic heterocyclic nitro compound as well as a preparation method and application thereof. The nitrogenous aromatic heterocyclic nitro compound has a structure as shown in a formula (III), wherein X, Y and Z

Nitrogen-containing aromatic heterocyclic diamine and preparation method thereof

The invention provides nitrogen-containing aromatic heterocyclic diamine and a preparation method thereof. The nitrogen-containing aromatic heterocyclic diamine has a structure as shown in a formula (III); and in the formula (III), X, Y and Z are independently selected from C or N, at least two of X, Y and Z are C, and R0 is selected from NH2 or a group shown in the specifiation. Compared with the prior art, the preparation method provided by the invention has the advantages that the nitrogen-containing aromatic heterocyclic diamine with the specific structure is prepared by adopting a one-step method, the route is simple, the operation is simple and convenient, the reaction is efficient (the conversion rate is high and the selectivity is good), the post-treatment is convenient, the reaction substrate is suitable for broad spectrum, and the preparation method is suitable for industrial mass production.

Diamine compound, polyimide film and flexible display device

The invention relates to the technical field of intelligent display, in particular to a diamine compound, a polyimide film and a flexible display device. The diamine compound has a structure shown ina formula (I) which is as shown in the specification, wherein the structure shown in the formula (I) meets one of the following conditions: i. at least one of A1-A4 is an N atom, the rest is -CH-, a structure shown in the specification is phenyl, five-membered heteroaryl or six-membered heteroaryl; ii. the A1-A4 are all -CH-, and the structure shown in the specification is five-membered aromatic heterocycles or six-membered aromatic heterocycles.

Preparation method of diamido nitrogen-containing aromatic heterocycle compound

The invention relates to the technical field of synthesis of compounds, in particular to a preparation method of diamido nitrogen-containing aromatic heterocycle compound. The preparation method includes mixing a compound having the structure as shown as the formula (I) with inorganic acid, reacting to obtain water-soluble organism, performing reduction reaction with a reducing agent sulfide to effectively reduce nitro-organism into amino-compounds, performing neutral reaction with alkali liquor so as to obtain the diamido nitrogen-containing aromatic heterocycle compound having the structureas shown as the formula (II) and having high yield and purity. The preparation method is simple and environmental friendly, is low in cost, needs mild reaction conditions, and is suitable to be popularized and applied in scale. According to tests, the yield of the diamido nitrogen-containing aromatic heterocycle compound prepared by the method is not lower than 90%, and even can reach 96%, and itspurity can reach 99.9%.