102573-86-4

Usage

Physical state

Clear, colorless liquid

Odor

Faint

Primary use

Solvent in manufacturing of adhesives, sealants, and coatings

Secondary use

Stabilizer in production of chlorinated solvents

Health risks

Probable human carcinogen

Hazardous exposure

Inhalation, ingestion, or skin absorption

Regulatory efforts

Ongoing to minimize exposure and protect human health and environment

Upstream product

• 4728-12-5 2,2-dimethyl-5-hydroxymethyl-1,3-dioxane 

Downstream Products

• 123522-73-6 (R)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-1-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,6-dimethyl-cyclohex-2-enol 
• 195534-87-3 2,2-Dimethyl-5-(5-trityloxy-hept-6-en-1-ynyl)-[1,3]dioxane 
• 1318792-89-0 methyl 3-{2-[2-(2,2-dimethyl-1,3-dioxan-5-yl)ethynyl]phenyl}propanoate 
• 123522-74-7 (S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-[(E)-2-(2,2-dimethyl-[1,3]dioxan-5-yl)-vinyl]-2,4-dimethyl-cyclohex-2-enone 
• 117479-71-7 (+)-Cassiol 
• 86611-21-4 <5-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2α,3β,4β,5α-tetrahydro-3,4-dihydroxy-2H-pyran-2-yl>-2-propanone 

Relevant academic research and scientific papers

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

ANTIBACTERIAL AGENTS

Antibacterial compounds of formula (I) are provided, as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

An Approach to Pseudomonic Acids from Acetylenic Precursors: Synthesis of 2-(Hydroxymethyl)-3-butyn-1-ol

The acetonide of 2-(hydroxymethyl)-3-butyn-1-ol (17) was prepared from bis(hydroxymethyl)malonate (11) or from 1,3-dihydroxypropanone (22).Alternative routes to 17 involving the intermediacy of highly unstable alkynal 21 or the corresponding acetate were unsuccessful.Condensation of the anion of 17 with aldehyde 30 followed by semihydrogenation and deprotection afforded keto triol 33, which cyclized stereoselectively to dihydropyran 34.Osmylation and functional group manipulation afforded 40 and 42, precursors to pseudomonic acid C (1).