1025731-83-2Relevant academic research and scientific papers
Glyoxylic Acid: A Carboxyl Group-Assisted Metal-Free Decarboxylative Reaction Toward Propargylamines
Huang, Liliang,Xie, Yujuan,Ge, Panyuan,Huang, Junhai,Feng, Huangdi
, p. 2448 - 2451 (2021)
Readily available propargylamines are not only fundamental building blocks in organic synthesis, but also possess many prominent biological activities. A highly efficient, concise and environmentally benign decarboxylative reaction of glyoxylic acid monohydrate with secondary amines and alkynes has been elaborated, and a variety of propargylamines are delivered in moderate to good yields under metal-free conditions. A mechanism involving a carboxyl group that assists the reactivity of alkynes, which makes the procedure of Michael addition proceeded smoothly, has been proposed.
Copper-catalyzed coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C-H activation
Niu, Mingyu,Yin, Zhengming,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
, p. 3961 - 3963 (2008/09/19)
(Chemical Equation Presented) We have developed a convenient and efficient method for coupling of tertiary aliphatic amines with terminal alkynes to propargylamines via C-H activation. The protocol uses CuBr as the catalyst, NBS as the free radical initia
