1025740-42-4Relevant articles and documents
Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, β amyloid aggregation, and Aβ neurotoxicity
Rizzo, Stefano,Rivière, Céline,Piazzi, Lorna,Bisi, Alessandra,Gobbi, Silvia,Bartolini, Manuela,Andrisano, Vincenza,Morroni, Fabiana,Tarozzi, Andrea,Monti, Jean-Pierre,Rampa, Angela
, p. 2883 - 2886 (2008)
The complex etiology of Alzheimer's disease (AD) prompts scientists to develop multitarget strategies to combat causes and symptoms. We therefore designed, synthesized, and tested new hybrid molecules linking a benzofuran ring to a N-methyl-N-benzylamine through a heptyloxy chain, affording a series of potential multifunctional drugs for AD. The Cholinesterase inhibitory activity was extended to the inhibition of Aβ fibril formation for 1, 3, and 5. Compound 3 showed an additional neuroprotective effect.