1025752-47-9Relevant academic research and scientific papers
Optimization of 1H-tetrazole-1-alkanenitriles as potent orally bioavailable growth hormone secretagogues
Hernandez, Andres S.,Swartz, Stephen G.,Slusarchyk, Dorothy,Yan, Mujing,Seethala, R. Krishna,Sleph, Paul,Grover, Gary,Dickinson, Kenneth,Giupponi, Leah,Harper, Timothy W.,Humphreys, W. Griffith,Longhi, Daniel A.,Flynn, Neil,Murphy, Brian J.,Gordon, David A.,Biller, Scott A.,Robl, Jeffrey A.,Tino, Joseph A.
, p. 2067 - 2072 (2008/12/21)
1H-Tetrazole-1-alkanenitrile SR-9g exhibits a >10-fold in vivo potency enhancement over the lead nitrile 1 and has acceptable oral bioavailability in rats and dogs. An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed.
