1025760-25-1

Basic information

• Product Name: 1-Methyl-1H-indole-3-carboxylic acid butyl ester
• Synonyms: 1-Methyl-1H-indole-3-carboxylic acid butyl ester
• CAS NO: 1025760-25-1
• Molecular Formula: C14H17NO2
• Molecular Weight: 231.29028
• Mol File: 1025760-25-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Methyl-1H-indole-3-carboxylic acid butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-1H-indole-3-carboxylic acid butyl ester(1025760-25-1)
• EPA Substance Registry System: 1-Methyl-1H-indole-3-carboxylic acid butyl ester(1025760-25-1)

Safety Data

• Hazardous Substances Data: 1025760-25-1(Hazardous Substances Data)

Usage

Derivative of indole

Heterocyclic aromatic compound The molecule is derived from the indole structure, which is a common compound found in plants and features a heterocyclic aromatic ring.

Usage in synthesis

Pharmaceutical, agrochemical, and dye industries This chemical is often utilized in the production of various products, such as pharmaceuticals, agrochemicals, and dyes, due to its unique structure and properties.

Biological activities

Anti-inflammatory and antioxidant properties The compound has been found to exhibit potential biological activities, including reducing inflammation and neutralizing harmful free radicals.

Building block in organic synthesis

Creating complex molecules 1-Methyl-1H-indole-3-carboxylic acid butyl ester can be used as a starting material to build more complex organic molecules with diverse applications across different industries.

Upstream product

• 1613389-64-2 (E)-butyl 3-(methyl(phenyl)amino)acrylate 
• 603-76-9 1-methylindole 
• 201230-82-2 carbon monoxide 
• 71-36-3 butan-1-ol 
• 120-72-9 indole 
• 31806-50-5 2-methyl-1-(1-methyl-1H-indol-3-yl)propan-1-one 
• 26501-54-2 tetrabutylammonium nitrite 

Relevant articles and documents

Palladium-catalyzed oxidative cyclization of tertiary enamines for synthesis of 1,3,4-trisubstituted pyrroles and 1,3-disubstituted indoles

A novel and efficient palladium-catalyzed intramolecular oxidative cyclization of tertiary enamines for the synthesis of 1,3,4-trisubstituted pyrroles and 1,3-disubstituted indoles has been developed. Trifluoroacetic acid plays an important role in the reaction. A series of pyrroles and indoles with substitution patterns that are not easily accessible by traditional routes were synthesized in good yields under mild conditions.

Regioselective Rh-catalyzed direct carbonylation of indoles to synthesize indole-3-carboxylates

Rh-catalyzed C-H carbonylation of indoles under 1 atm of CO has been achieved. Various substituted indoles and indole with free N-H could be carboxylated with linear- and/or cyclic-alcohol to give the desired indole-3-carboxylates with up to 92% yield. A mechanism involving Rh III initiated C-H metallation is proposed.

Copper-catalyzed synthesis of esters from ketones. Alkyl group as a leaving group

The conversion of ketones to esters has been achieved through the use of Cu catalyst and tetrabutylammonium nitrite. This reaction involves the activation of the less activated C-C bond, and the alkyl group is removed as a leaving group. Various isopropyl ketones are found to be good substrates for this reaction.