1025804-84-5Relevant academic research and scientific papers
Tandem cyclization: One pot regioselective synthesis of thieno[3,2-c]quinolin-4(5H)-one derivatives
Majumdar,Ghosh
, p. 10047 - 10052 (2007/10/03)
A number of hitherto unreported 3-(aryloxyacetyl)-2,3-dihydro-5-alkylthieno[3,2-c]quinolin-4(5H)-ones are regioselectively synthesized in 80-90% yield from 4-(4′-aryloxybut-2′-ynyl)thioquinolin-2(1H)-ones by the oxidation with 1equiv. of m-CPBA at 0-5°C for 1h followed by heating under reflux in chloroform and subsequent treatment with 20% aqueous KOH. The substrate, sulfides were prepared by PTC alkylation of 4-mercaptoquinolin-2(1H)-one with 1-aryloxy-4-chlorobut-2-ynes.
