1025812-82-1Relevant academic research and scientific papers
8-HYDROXY-SUBSTITUTED ISOCOUMARINS BY LITHIATION OF BENZENE DERIVATIVES PROMOTED BY β-FUNCTIONALISED ALKYL GROUPS. A REGIOSELECTIVE AND SIMPLE SYNTHESIS OF OOSPOLACTONE
Ramacciotti, Alessio,Fiaschi, Rita,Napolitano, Elio
, p. 111 - 114 (2007/10/02)
3-(3-hydroxyphenyl)-2-butanone (obtained in 3 steps from 3-bromophenol and 3-chloro-2-butanone) was ketalised with ethylene glycol and protected at the phenolic OH as the methoxymethyl ether.The intermediate diacetal thus obtained underwent hydrogen-metal exchange with n-butyllithium; the metallated intermediate, after carbonation, methanolysis of acetal groups and elimination of methanol, regioselectively afforded the title compound (8-hydroxy-3,4-dimethylisocoumarin).
