1025813-99-3

Upstream product

• 777059-33-3 methyl 3-hydroxy-3-[2-(3-hydroxypropyn-1-yl)]phenyl-2-methylenepropanoate 
• 396717-19-4 2-(3-hydroxyprop-1-yn-1-yl)benzaldehyde 
• 1027519-96-5 methyl 3-acetoxy-3-[2-(3-acetoxypropyn-1-yl)]phenyl-2-methylenepropanoate 

Relevant academic research and scientific papers

Synthesis of 5H-1,2,3-triazolo[4,3-a][2]benzazepines from the Baylis-Hillman adducts of 2-alkynylbenzaldehydes

The facile synthesis of 5H-1,2,3-triazolo[4,3-a][2]benzazepines 5a-d by the intramolecular 1,3-dipolar cycloaddition reaction of 2-alkynylphenylallyl azides 4a-d is described. The latter were readily obtained from 2-alkynylbenzaldehydes 1a-d through the Baylis-Hillman adducts 2a-d followed by acetylation to compounds 3a-d and nucleophilic substitution by azide to compounds 4a-d.