1025814-94-1

Basic information

• Product Name: 6-(3-CHLOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 6-(3-CHLOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER;ethyl 6-(3-chlorophenyl)-3-methylimidazo[2,1-b]thiazole-2-carboxylate
• CAS NO: 1025814-94-1
• Molecular Formula: C15H13ClN2O2S
• Molecular Weight: 320.79
• Mol File: 1025814-94-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 4.66±0.40(Predicted)
• CAS DataBase Reference: 6-(3-CHLOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(3-CHLOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(1025814-94-1)
• EPA Substance Registry System: 6-(3-CHLOROPHENYL)-3-METHYLIMIDAZO[2,1-B]THIAZOLE-2-CARBOXYLIC ACID ETHYL ESTER(1025814-94-1)

Safety Data

• Hazardous Substances Data: 1025814-94-1(Hazardous Substances Data)

Relevant articles and documents

IMIDAZO[2, 1-B]THIAZOLES AND THEIR USE AS PHARMACEUTICALS

The present invention relates to derivatives of imidazo[2,1-b]thiazoles of the formula (I), in which R, R1 to R3 and n have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) synthase and are valuable pharmacologically active compounds. Specifically, the compounds of the formula I upregulate the expression of the enzyme endothelial NO synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention further relates to processes for the preparation of compounds of the formula I, to pharmaceutical compositions comprising them, and to the use of compounds of the formula I for the manufacture of a medicament for the stimulation of the expression of endothelial NO synthase or for the treatment of various diseases including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency, for example.