1025874-83-2Relevant academic research and scientific papers
One-pot three-step solution phase syntheses of thiohydantoins using microwave heating
?hberg,Westman
, p. 1893 - 1896 (2001)
An efficient one-pot three-step solution phase protocol suitable for library syntheses of thiohydantoins was developed. The reactions included are in the following order, Negishi or Suzuki C-C coupling reactions, reductive amination and finally a cyclisation reaction. Protocols using a solid supported reagent and protocols suitable for combinatorial chemistry were developed, all including microwave heating.
