102589-13-9Relevant academic research and scientific papers
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors
Chen, Shaoqing,Chen, Li,Le, Nam T.,Zhao, Chunlin,Sidduri, Achyutharao,Lou, Jian Ping,Michoud, Christophe,Portland, Louis,Jackson, Nicole,Liu, Jin-Jun,Konzelmann, Fred,Chi, Feng,Tovar, Christian,Xiang, Qing,Chen, Yingsi,Wen, Yang,Vassilev, Lyubomir T.
, p. 2134 - 2138 (2008/02/03)
A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK1 activity in vitro, and block cell cycle progression in human tumor cell lines, suggesting a potential use as antitumor agents.
Thiazolinone 4-monosubstituted quinolines
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Page/Page column 25, (2010/10/20)
Thiazolinone monosubstituted quinoline derivatives where the quinoline ring is mono-substituted at the 4 positions which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents.
Azaindole thiazolinones
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Page/Page column 12, (2010/10/20)
Azaindole thiazolinone derivatives which demonstrate CDK1 and CDK2 antiproliferative activities and are useful as anti-cancer agents.
Quinazoline thiazolinones
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Page/Page column 13, (2008/06/13)
Quinazoline thiazolinone derivatives which demonstrate CDK1 antiproliferative activity and are useful as anti-cancer agents.
Substituted 1,5-naphthyridine azolinones
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Page/Page column 12, (2010/11/24)
Substituted 1,5-naphthyridine azolinones inhibit Cdk1 and are selective against Cdk2 and Cdk4. These compounds and their pharmaceutically acceptable salts have antiproliferative activity and are useful as anti-cancer agents.
