10259-18-4Relevant articles and documents
Normal Vibrations of 4-Methyl- and 4-Methyl-d3-pyridines
Yoshikai, Kazumasa,Hieida, Toshikazu,Nibu, Yoshinori,Shimada, Hiroko,Shimada, Ryoichi
, p. 1529 - 1531 (1990)
Assignment of the normal vibrations of 4-methylpyridine was made through the vibrational analyses of the Raman and infrared spectra and also through the normal coordinate calculation.The assignment was confirmed by the study made on 4-methyl-d3-pyridine.
A facile and general acid-catalyzed deuteration at methyl groups of N-heteroarylmethanes
Liu, Min,Chen, Xue,Chen, Tieqiao,Yin, Shuang-Feng
, p. 2507 - 2511 (2017)
A facile and general Br?nsted acid-catalyzed deuteration at the methyl group of N-heteroarylmethanes was achieved through a dearomatic enamine intermediate under relatively mild reaction conditions. Both 2-methyl and 4-methyl groups in quinolines were deuterated with high deuterium incorporation. Pyridines, benzo[d]thiazoles, indoles and imines including these clinical drugs were also deuterated efficiently at the methyl groups. This reaction could be conducted on a large scale (500 mmol), showing its good potential for use in large-scale synthesis.
SITE SELECTIVE EFFECT OF N-OXIDE FUNCTION TO METHYL GROUPS ON SIX-MEMBERED N-HETEROAROMATICS
Sakamoto, Takao,Yoshizawa, Hiroshi,Yamanaka, Hiroshi,Goto, Yoshinobu,Niiya, Tokihiro,Honjo, Noriko
, p. 73 - 76 (2007/10/02)
Reaction of 2,4-dimethylpyridine 1-oxide with ethyl benzoate under basic conditions afforded 4-methyl-2-phenacylpyridine 1-oxide, while the same reaction of 2,4-dimethylpyridine itself is known to afford 2-methyl-4-phenacylpyridine.Concerning the above contrast, the effect of N-oxide function to the relative reactivity of the 2- and 4-methyl group was investigated on pyridine, quinoline, pyrimidine, and quinazoline homologues.The higher reactivity of α-methyl groups was concluded to be general in the N-oxides of these N-heteroaromatics.
