1025914-50-4

Basic information

• Product Name: 6-Chloro-3-phenyl-1,2,4-triazine
• Synonyms: 6-Chloro-3-phenyl-1,2,4-triazine;1,2,4-Triazine,6-chloro-3-phenyl-
• CAS NO: 1025914-50-4
• Molecular Formula: C9H6ClN3
• Molecular Weight: 192
• Mol File: 1025914-50-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.309
• CAS DataBase Reference: 6-Chloro-3-phenyl-1,2,4-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-3-phenyl-1,2,4-triazine(1025914-50-4)
• EPA Substance Registry System: 6-Chloro-3-phenyl-1,2,4-triazine(1025914-50-4)

Safety Data

• Hazardous Substances Data: 1025914-50-4(Hazardous Substances Data)

Usage

Chemical Class

Triazine

Functional Groups

Chlorine atom and Phenyl group attached to a triazine ring

Applications

Medicinal chemistry, synthesis of pharmaceuticals and agrochemicals, building block in organic synthesis, other industrial uses

Potential Hazards

May present certain hazards, precautions should be taken when handling and using it

Upstream product

• 84586-28-7 3-phenyl-1,2,4-triazinone 

Relevant articles and documents

Aminopyridazines as acetylcholinesterase inhibitors

Following the discovery of the weak, competitive and reversible acetylcholinesterase (AChE)-inhibiting activity of minaprine (3c) (IC50 = 85 μM on homogenized rat striatum AChE), a series of 3-amino-6- phenylpyridazines was synthesized and tested for inhibition of AChE. A classical structure-activity relationship exploration suggested that, in comparison to minaprine, the critical elements for high AChE inhibition are as follows: (i) presence of a central pyridazine ring, (ii) necessity of a lipophilic cationic head, (iii) change from a 2- to a 4-5-carbon units distance between the pyridazine ring and the cationic head. Among all the derivatives investigated, 3-[2-(1-benzylpiperidin-4-yl)ethylamino]-6- phenylpyridazine (3y), which shows an IC50 of 0.12 μM on purified AChE (electric eel), was found to be one of the most potent anti-AChE inhibitors, representing a 5000-fold increase in potency compared to minaprine.