1025933-75-8

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 146380-12-3 5-(1-hydroxy-3-methylbutylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 108-12-3 isopentanoyl chloride 

Relevant academic research and scientific papers

Microwave-assisted solution-phase synthesis of 1,4,5-trisubstituted pyrazoles

A small parallel library of 1,4,5-trisubstituted pyrazoles was prepared in solution using a three-step procedure starting from Meldrum acid. The Meldrum acid was acylated with different acyl chlorides and the products opened with different alcohols and amines to give substituted β-keto esters and β-keto amines. Further reaction with N,N-dimethylformamide dimethylacetal and the final cyclisation were effectively carried out under microwave irradiation. Scavenger resins were employed exclusively in the first step, whereas use of microwaves allowed complete conversion of the starting materials in the other two steps. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.