1026-33-1Relevant academic research and scientific papers
FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE
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Paragraph 0056; 00159; 00162-00163; 00180-00182; 00198-00200, (2021/01/23)
The present application provides furosemide analogues of the general formula Z having activity as anti-Aβ aggregation agents and/or as inhibitors of Aβ induced neuroinflammation. Formula Z These compounds are useful in preventing, delaying and/or treating Alzheimer's Disease. Accordingly, the present application further provides pharmaceutical compositions and method for preventing, delaying and/or treating Alzheimer's Disease.
Copper catalyzed C-N bond formation/C-H activation: Synthesis of aryl 4H-3,1-benzoxazin-4-ones
Munusamy, Sathishkumar,Venkatesan, Sathesh,Sathiyanarayanan, Kulathu Iyer
supporting information, p. 203 - 205 (2015/02/02)
We have developed a practical and efficient synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one derivatives through copper catalyzed tandem reaction of 2-iodobenzoic acid with arylmethanamines under aerobic conditions. Compared to the literature methods toward the synthesis of 2-phenyl-4H-benzo[d][1,3]oxazine-4-one, the synthetic method reported in this Letter has broad substrate scope, mild reaction condition, and uses an inexpensive catalyst.
