1026-63-7Relevant articles and documents
Synthesis of functional isoxazole derivatives proceeding from (5-arylisoxazol-3-yl)chloromethanes
Potkin,Bumagin,Petkevich,Dikusar,Semenova,Kurman,Zolotar',Pashkevich,Gurinovich,Kul'Chitskii
, p. 1119 - 1130 (2015/10/12)
Reaction of 3-chloromethyl-5-phenyl(p-tolyl)isoxazoles with substituted phenols under the conditions of Williamson reaction afforded the corresponding 3-aryloxymethyl-5-phenyl(p-tolyl)isoxazoles. Treating the latter with sodium methylate, sodium phenyl(benzyl, furfuryl)thiolates and morpholine in methanol resulted in the replacement of the chlorine atom in 3-chloromethyl-5-phenyl(p-tolyl)isoxazoles by methoxy-, phenyl-(benzyl, furfuryl)sulfanyl groups and morpholine residue.
