1026-89-7Relevant academic research and scientific papers
A short synthesis of d-sotalol
Smith,Brodfuehrer,Dillon,Vemishetti
, p. 1093 - 1098 (1995)
Asymmetric synthesis of d-sotalol (2) was accomplished by chiral homogenous hydrogenation of (4-isopropylaminoacetyl)methanesulfonanilide hydrochloride (1).
The Ru-catalyzed enantioselective preparation of chiral halohydrins and their application in the synthesis of (R)-clorprenaline and (S)-sotalol
Lu, Chuanjun,Luo, Zonghua,Huang, Ling,Li, Xingshu
experimental part, p. 722 - 727 (2011/08/06)
The asymmetric transfer hydrogenation of a series of halo-substituted aryl methyl ketones, including those substituted in both α-methyl and aryl rings, was studied for the preparation of chiral halohydrins. Up to 99.7% ee was obtained with 2-chloro-1-(2-chlorophenyl)ethanone as the substrate and Ru-CsDPEN as the catalyst in an HCOONa/H2O system. (R)-Clorprenaline, a drug used in the treatment of respiratory disorders, such as bronchitis and asthma, and (S)-sotalol, a class-III antiarrhythmic compound, were prepared with these chiral halohydrins.
Synthesis of (S)-(+)-sotalol and (R)-(-)-isoproterenol via a catalytic enantioselective Henry reaction
Blay, Gonzalo,Hernandez-Olmos, Victor,Pedro, Jose R.
experimental part, p. 578 - 581 (2010/08/06)
A unified approach for the synthesis of (S)-(+)-sotalol and (R)-(-)-isoproterenol has been developed. The enantioselective Henry reaction of the appropriate aldehyde in the presence of a camphor-derived amino pyridine-Cu(II) complex was the key step of th
Combination of a potassium channel activator and an antiarrhythmic agent
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, (2008/06/13)
A method for the concomitant treatment of ischemia and arrhythmia in mammalian species which includes administering a combination of a potassium channel opener having little or no effect on action potential duration in the heart and a class III antiarrhythmic compound.
