102601-49-0

Usage

Uses

Used in Biochemistry Research:
3BETA-HYDROXY-5-CHOLESTENE 3-HEMISUCCINATE TRIS SALT is used as a solubilization agent for preparing solubilization buffer for glucan synthase assay and immunoprecipitation buffer for immobilization of opioid receptors on paramagnetic beads. Its ability to solubilize proteins and membranes aids in the study and analysis of these biological molecules.
Used in Pharmaceutical Industry:
3BETA-HYDROXY-5-CHOLESTENE 3-HEMISUCCINATE TRIS SALT is used as a membrane stabilizer for liposomes and protein synaptogyrin-1. It helps in maintaining the stability and integrity of these structures, which is crucial for their function and effectiveness in drug delivery.
Used in Drug Delivery Systems:
3BETA-HYDROXY-5-CHOLESTENE 3-HEMISUCCINATE TRIS SALT is used as a component of a folate-modified self-microemulsifying drug delivery system. Its solubilizing properties enhance the delivery and bioavailability of drugs, improving their therapeutic outcomes.
Used in Combination with Other Solubilizing Agents:
3BETA-HYDROXY-5-CHOLESTENE 3-HEMISUCCINATE TRIS SALT is used in conjunction with N-dodecyl β-D-maltoside (DDM) to solubilize erythrocyte ghosts and chemokine receptor CCR1. This combination enhances the solubility and functionality of these proteins, facilitating their study and potential applications in research and therapeutics.

Biochem/physiol Actions

Cholesteryl hemisuccinate is an ionizable anionic detergent that stabilizes large unilamellar vesicles. These liposome vesicles act as delivery agents for anticancer drugs, oligonucleotides and antibiotics. Cholesteryl succinate also reportedly exhibits antiproliferative activity and may be clinically useful as antitumor agent.