1026023-07-3Relevant academic research and scientific papers
Unnatural amino acids. 3*. Aziridinyl ketones from esters and amides of aziridine-2-carboxylic acids
Shtrumfs,Hermane,Kalvinsh,Trapencieris
, p. 169 - 174 (2008/12/21)
A series of N-substituted amides and esters of aziridine-2-carboxylic acids have been prepared and have been subjected to deprotonation with lithium diisopropylamide. The intermediate carbanions reacted more readily with the carbonyl groups of the substrates than with methyl iodide. So, in place of the expected amides or esters of methylaziridine-2-carboxylic acids, amides or esters of 2-aziridinylcarbonylaziridine-2-carboxylic acids were isolated.
