1026024-87-2Relevant academic research and scientific papers
Indium(III) Chloride Promoted Highly Efficient Tandem Rearrangement-α-Addition Strategy towards the Synthesis of α-Hydroxyamides
Lingaswamy, Kadari,Mohan, Dumpala,Krishna, Palakodety Radha,Prapurna, Y. Lakshmi
, p. 1693 - 1698 (2016)
A new tandem process is reported that provides access to α-hydroxyamides from epoxides for the first time. Herein, we explore InCl3-mediated tandem rearrangement of epoxides to aldehydes and α-addition of TosMIC to in situ derived aldehydes. An unprecedented C-C bond-forming reaction is disclosed that features mild conditions, high yields, and shorter reaction times.
