1026029-69-5

Basic information

• Product Name: 7-{3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-(2,4-difluoro-benzenesulfonylamino)-butyl]-cyclopentyl}-heptanoic acid methyl ester
• CAS NO: 1026029-69-5
• Molecular Weight: 850.384
• Mol File: 1026029-69-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-{3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-(2,4-difluoro-benzenesulfonylamino)-butyl]-cyclopentyl}-heptanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 7-{3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-(2,4-difluoro-benzenesulfonylamino)-butyl]-cyclopentyl}-heptanoic acid methyl ester(1026029-69-5)
• EPA Substance Registry System: 7-{3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-[3-(tert-butyl-dimethyl-silanyloxy)-4-(2,4-difluoro-benzenesulfonylamino)-butyl]-cyclopentyl}-heptanoic acid methyl ester(1026029-69-5)

Safety Data

• Hazardous Substances Data: 1026029-69-5(Hazardous Substances Data)

Upstream product

• 303963-61-3 7-[2-[4-azido-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-cyclopentyl]-heptanoic acid methyl ester 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 13918-92-8 2,4-difluorobenzene-1-sulfonyl chloride 
• 303963-80-6 7-[2-[4-amino-3-(tert-butyl-dimethyl-silanyloxy)-butyl]-3,5-bis-(tert-butyl-dimethyl-silanyloxy)-cyclopentyl]-heptanoic acid methyl ester 

Relevant articles and documents

The synthesis and human FP receptor binding affinity of 13,14-dihydro prostaglandia F1(α) sulfonamides: Potential treatments for osteoporosis

A novel class of saturated prostaglandin F(2α) sulfonamide analogs have been synthesized and evaluated in the human FP receptor binding assay for potential use in the treatment of osteoporosis. These compounds have been modified at the C1 carboxylic acid moiety and at the C16 - C20 region of the prostaglandin. Based on the structure-activity relationships, it was found that at C1, the aryl sulfonamide analogs possessed greater affinity for the hFP receptor when compared to alkyl sulfonamides. When the sulfonamide was introduced into the C16 - C20 region (omega chain) of the prostaglandin, a significant reduction in binding was observed. These results are discussed within the framework of a proposed model for the human FP receptor.