102608-51-5Relevant academic research and scientific papers
Convenient Synthesis of Stereospecifically Deuteriated Glycines from Glutamic Acid using a Combination of Enzymatic and Chemical Methods
Santaniello, Enzo,Casati, Rosangela,Manzocchi, Ada
, p. 2389 - 2392 (2007/10/02)
Chiral glycines (1a) and (1b) have been synthesized starting from stereospecifically deuteriated 4-aminobutanoic acids (3a) and (3b).Enzymatic decarboxylation of (2S)-glutamic acid (2a) in (2)H2O and (2R,S)-glutamic acid (2b) + (2c) in H2O afforded (3a) and (3b), respectively.Chemical transformations of deuteriated pyrrolidinones (4a) and (4b) afforded stereospecifically labelled glycines (1a) and (1b) in good yields.
