1026084-85-4

Upstream product

• 503004-96-4 (1R,2S,4aS,7R,8aR,9aS)-4,4,7-trimethyl-1-phenyl-2-vinyldecahydro-9-oxa-3a-azacyclopenta[b]naphthalen-1-ol 
• 503005-01-4 (3R,4S,1'S,2'R,4'R)-1-[1'-(2'-hydroxy-4'-methylcyclohexyl)-1'-methylethyl]-3-phenyl-4-vinylpyrrolidin-3-ol 

Relevant academic research and scientific papers

Temperature- and time-dependent stereochemical control in thermally induced keto-ene cyclizations

Reaction conditions determine the stereoselection in the intramolecular keto-ene reaction. The thermolysis of chiral 2-acyl-3-allyl-substituted 1,3-perhydrobenzoxazines derived from (-)-8-aminomenthol gives a mixture of only two cis-3-hydroxy-3,4-disubstituted pyrrolidine nuclei. The stereochemistry of the major diastereoisomer depends on both the temperature and the reaction time.