102609-89-2

Upstream product

• 102609-87-0 1-(2'-(dimethoxymethyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal 
• 67643-58-7 1,2,3,10,11,11a-hexahydro-5H-pyrrolo<1,2-b><2>benzazepine-5,10-dione 
• 67643-65-6 1,2,3,10,11,11a-hexahydro-10-hydroxy-5H-pyrrolo<1,2-b><2>benzazepine-5-one 
• 102609-86-9 1,2,3,11a-tetrahydropyrrolo<1,2-b><2>benzazepin-5-one 
• 102609-88-1 1-(2'-formylbenzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal 

Downstream Products

• 102609-92-7 1-(2'-(((2-(trimethylsilyl)ethoxy)carbonyl)amino)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal 
• 102609-91-6 (2-Dimethoxymethyl-pyrrolidin-1-yl)-(2-isocyanato-phenyl)-methanone 
• 53616-64-1 1-(2'-aminobenzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal 
• 123266-95-5 1-(2'-(azidocarbonyl)benzoyl)-2-pyrrolidinecarboxaldehyde dimethyl acetal 

Relevant academic research and scientific papers

Photochemical Approach to the Synthesis of the Pyrrolobenzodiazepine Antibiotics

The total syntheses of the pyrrolobenzodiazepine antitumor antibiotics prothracarcin and DC-81 were realized using, as a key step, the photochemical ring expansion of the appropriately substituted N-pentenylphthalimide to afford the corresponding pyrrolobenzazepinedione.Conversion of the photoproduct into the antibiotic skeleton was effected by transformation of the benzylic ketone into a carbinolamine via a Curtius rearrangement sequence.

A PHOTOCHEMICAL ROUTE TO PYRROLOBENZODIAZEPINE ANTITUMOR ANTIBIOTICS

The parent pyrrolobenzodiazepine ring system was synthesized.The key step was the photostimulated ring expansion reaction of N-pentenylphtalimide to give a pyrrolobenzazepinedione photoproduct.Conversion of the pyrrolobenzazepinedione ring system to