102617-49-2

Basic information

• Product Name: Cyclohexanepropanoic acid, a-(cyclohexylmethyl)-
• Synonyms: 3-Cyclohexyl-2-(cyclohexylmethyl)propanoic acid
• CAS NO: 102617-49-2
• Molecular Formula: C₁₆H₂₈O₂
• Molecular Weight: 252.397
• Mol File: 102617-49-2.mol

Chemical Properties

• Boiling Point: 380.9 °C at 760 mmHg
• Flash Point: 181.3 °C
• Density: 0.991 g/cm³
• CAS DataBase Reference: Cyclohexanepropanoic acid, a-(cyclohexylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanepropanoic acid, a-(cyclohexylmethyl)-(102617-49-2)
• EPA Substance Registry System: Cyclohexanepropanoic acid, a-(cyclohexylmethyl)-(102617-49-2)

Safety Data

• Hazardous Substances Data: 102617-49-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Cyclohexanepropanoic acid, a-(cyclohexylmethyl)is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique stereochemistry and potential biological activity contribute to the development of new drugs and pesticides with improved efficacy and selectivity.
Used in Flavor and Fragrance Industries:
In the flavor and fragrance industry, Cyclohexanepropanoic acid, a-(cyclohexylmethyl)is used as a component of perfumes and food additives. Its distinct aroma and flavor characteristics enhance the sensory experience of various products, making them more appealing to consumers.
Used in Anti-inflammatory and Analgesic Applications:
Cyclohexanepropanoic acid, a-(cyclohexylmethyl)has been studied for its potential anti-inflammatory and analgesic properties. Its unique structure may contribute to modulating inflammatory pathways and providing pain relief, making it a promising candidate for the development of new therapeutic agents in the medical field.

Upstream product

• 5469-33-0 cyclohexylmethyl iodide 
• 618-68-8 2-benzyl-3-phenylpropanoic acid 

Downstream Products

• 1383115-96-5 (2-fluoropropane-1,3-diyl)dicyclohexane 
• 1360825-93-9 (2-chloropropane-1,3-diyl)dicyclohexane 
• 188822-40-4 bis-(cyclohexylmethyl)acetyl chloride 

Relevant articles and documents

Steric Effect of Carboxylate Ligands on Pd-Catalyzed Intramolecular C(sp2)–H and C(sp3)–H Arylation Reactions

A bulky carboxylic acid bearing three cyclohexylmethyl substituents at the α-position, namely, tri(cyclohexylmethyl)acetic acid, is demonstrated to act as an efficient ligand source in Pd-catalyzed intramolecular C(sp2)?H and C(sp3)?H arylation reactions. The reactions proceed smoothly under mild reaction conditions, even at room temperature due to the steric bulk of the carboxylate ligands, which accelerates the rate-determining C?H bond activation step in the catalytic cycle.

ACYLATED AMINO ACIDS AS ENDOTHELIN ANTAGONISTS

Novel acylated amino acids which are antagonists of endothelin are described. Methods for their preparation and pharmaceutical compositions containing them are also included. The compounds are expected to be useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, diabetes, head injury, and stroke.