1026223-11-9

Basic information

• Product Name: 3-[[(cyclohexylamino)carbonyl]oxy]-1-aminoadamantane
• Synonyms: 3-[[(cyclohexylamino)carbonyl]oxy]-1-aminoadamantane
• CAS NO: 1026223-11-9
• Molecular Weight: 292.422
• Mol File: 1026223-11-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[[(cyclohexylamino)carbonyl]oxy]-1-aminoadamantane(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[[(cyclohexylamino)carbonyl]oxy]-1-aminoadamantane(1026223-11-9)
• EPA Substance Registry System: 3-[[(cyclohexylamino)carbonyl]oxy]-1-aminoadamantane(1026223-11-9)

Safety Data

• Hazardous Substances Data: 1026223-11-9(Hazardous Substances Data)

Upstream product

• 565453-43-2 benzyl ((3-hydroxy)adamantan-1-yl)carbamate 
• 3173-53-3 Cyclohexyl isocyanate 
• 702-82-9 3-aminoadamantan-1-ol 
• 620171-62-2 (3-cyclohexylcarbamoyloxy-adamantan-1-yl)-carbamic acid benzyl ester 

Relevant articles and documents

1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties

Dipeptidyl peptidase IV (DPP-IV) inhibition has the potential to become a valuable therapy for type 2 diabetes. The synthesis and structure - activity relationship of a new DPP-IV inhibitor class, N-substituted-glycyl-2-cyanopyrrolidines, are described as well as the path that led from clinical development compound 1-[2-[5-cyanopyridin-2-yl)amino]ethylamino]acetyl-2-cyano-(S)pyrrolidine (NVP-DPP728, 8c) to its follow-up, 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)pyrrolidine (NVP-LAF237, 12j). The pharmacological profile of 12j in obese Zucker fa/fa rats along with pharmacokinetic profile comparison of 8c and 12j in normal cynomolgus monkeys is discussed. The results suggest that 12j is a potent, stable, selective DPP-IV inhibitor possessing excellent oral bioavailability and potent antihyperglycemic activity with potential for once-a-day administration.