1026224-88-3Relevant academic research and scientific papers
Taurospongin A, a Novel Acetylenic Fatty Acid Derivative Inhibiting DNA Polymerase β and HIV Reverse Transcriptase from Sponge Hippospongia sp
Ishiyama, Haruaki,Ishibashi, Masami,Ogawa, Akio,Yoshida, Shonen,Kobayashi, Jun'ichi
, p. 3831 - 3836 (2007/10/03)
Taurospongin A (1), a novel acetylene-containing natural product consisting of a taurine and two fatty acid residues, has been isolated from the Okinawan marine sponge Hippospongia sp. and its structure elucidated by spectral data and chemical means. Taurospongin A (1) exhibited potent inhibitory activity against DNA polymerase β and HIV reverse transcriptase. The absolute configurations of taurospongin A (1) were established to be 3R, 7S, and 9R by synthesis of the MTPA ester of a degradation product of 1.
