1026237-33-1Relevant academic research and scientific papers
Palladium-Catalyzed Cross-Coupling Syntheses of Benzotriazolyl Enynes and a General Route to Enynyl Ketones and Alkynyl Ketones
Katritzky, Alan R.,Yao, Jiangchao,Qi, Ming
, p. 8201 - 8204 (2007/10/03)
A new general route to conjugated enynyl ketones was developed based on a two-step procedure. First, palladium-catalyzed cross-coupling reactions of 1-(benzotriazol-1-yl)propargyl ethyl ether (3) and vinyl triflates or vinyl bromides afforded the key intermediates [1-(benzotriazol-1-yl)-1-enynyl]-methyl ethyl ethers 5a-d in good yields. Then reactions of compounds 5 with primary halides gave intermediates 8, which were hydrolyzed by dilute acid to enynyl ketones 9a-g. Similar palladium-catalyzed coupling reactions of 3 with various aryl iodides followed by an analogous sequence afforded aryl-substituted propargyl ethers 12a-d and thence alkynyl ketones 13a,b.
