102624-26-0Relevant articles and documents
Synthesis and Structure-Activity Relationships of a Novel Class of 5-Lipoxygenase Inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: The Development of L-656,224
Lau, Cheuk K.,Belanger, Patrice C.,Scheigetz, John,Dufresne, Claude,Williams, Haydn W. R.,et al.
, p. 1190 - 1197 (2007/10/02)
The synthesis of a series of 2-(phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans and their inhibitory effects against leukotriene biosynthesis and 5-lipoxygenase activity in vitro are described.Many compounds of this series were found to be potent inhibitor
Benzofuran derivatives useful as inhibitors of mammalian leukotriene biosynthesis
-
, (2008/06/13)
Benzofuran derivatives, pharmaceutical compositions and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic condit