1026272-47-8

Basic information

• Product Name: 2-amino-N-(2,6-diethyl-phenyl)-5-nitro-benzamide
• CAS NO: 1026272-47-8
• Molecular Weight: 313.356
• Mol File: 1026272-47-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-N-(2,6-diethyl-phenyl)-5-nitro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-(2,6-diethyl-phenyl)-5-nitro-benzamide(1026272-47-8)
• EPA Substance Registry System: 2-amino-N-(2,6-diethyl-phenyl)-5-nitro-benzamide(1026272-47-8)

Safety Data

• Hazardous Substances Data: 1026272-47-8(Hazardous Substances Data)

Upstream product

• 579-66-8 2,6-diethylaniline 
• 616-79-5 2-amino-5-nitro-benzoic acid 

Relevant articles and documents

Specific nonpeptide inhibitors of puromycin-sensitive aminopeptidase with a 2,4(1H,3H)-quinazolinedione skeleton.

Potent, specific, chemically stable and non-peptide/small-molecular inhibitors of puromycin-sensitive aminopeptidase, such as 3-(2,6-diethylphenyl)-2,4(1H,3H)-quinazolinedione (PAQ-22, 5), were prepared by the structural development of a potent PSA inhibitor, 2-(2,6-diethylphenyl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (PIQ-22, 4). The design was carried out partly by applying electrostatic potential field information obtained from PIQ-22 (4) and its derivatives based on thalidomide (2). This information revealed that a positive electrostatic potential field around the benzylic methylene in the tetrahydroisoquinoline ring is necessary for potent activity. Lineweaver-Burk plot analysis showed that PAQ-22 (5) and its derivatives inhibit puromycin-sensitive aminopeptidase (PSA) in a non-competitive manner. These potent and specific PSA inhibitors showed dose-dependent cell invasion-inhibitory activity in a Matrigel assay using mouse melanoma B16F10/L5 cells, in spite of their low cell toxicity.