102629-66-3Relevant articles and documents
Multivalent alteration of quorum sensing in Staphylococcus aureus
Melamed Yerushalmi, Sarit,Buck, Maren E.,Lynn, David M.,Lemcoff, N. Gabriel,Meijler, Michael M.
supporting information, p. 5177 - 5179 (2013/06/27)
Virulence in Staphylococcus aureus is strongly and positively correlated with local cell density. Here we present an effective approach to modulate this group behaviour using multivalent peptide-polymer conjugates. Our results show that by attaching multiple AIP-4′ units to macromolecular scaffolds, the agr QS response in S. aureus was affected strongly, while displaying a clear multivalency effect.