102630-86-4

Basic information

• Product Name: 3-AMINO-N-(2,3-DIMETHYLPHENYL)BENZAMIDE
• Synonyms: UKRORGSYN-BB BBV-023992;3-amino-N-(2,3-dimethylphenyl)benzamide(SALTDATA: FREE);3-AMINO-N-(2,3-DIMETHYLPHENYL)BENZAMIDE;CBI-BB ZERO/006492;OTAVA-BB 1056945;Benzamide, 3-amino-N-(2,3-dimethylphenyl)-
• CAS NO: 102630-86-4
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.31
• Mol File: 102630-86-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 351.1°C at 760 mmHg
• Flash Point: 166.2°C
• Appearance: /
• Density: 1.182g/cm³
• Vapor Pressure: 4.2E-05mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 3-AMINO-N-(2,3-DIMETHYLPHENYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N-(2,3-DIMETHYLPHENYL)BENZAMIDE(102630-86-4)
• EPA Substance Registry System: 3-AMINO-N-(2,3-DIMETHYLPHENYL)BENZAMIDE(102630-86-4)

Safety Data

• Hazardous Substances Data: 102630-86-4(Hazardous Substances Data)

Usage

General Description

3-AMINO-N-(2,3-DIMETHYLPHENYL)BENZAMIDE is a chemical compound with the molecular formula C15H16N2O. It is an amide derivative of benzene and contains an amino group and a dimethylphenyl group. 3-AMINO-N-(2,3-DIMETHYLPHENYL)BENZAMIDE is used in various chemical reactions and synthetic processes, and it has potential applications in pharmaceutical research and drug development. Its specific properties and potential uses may vary depending on the context and the specific requirements of the intended application.

InChI:InChI=1/C15H16N2O/c1-10-5-3-8-14(11(10)2)17-15(18)12-6-4-7-13(16)9-12/h3-9H,16H2,1-2H3,(H,17,18)

Upstream product

• 121-90-4 m-nitrobenzoic acid chloride 
• 87-59-2 2,3-Dimethylaniline 
• 102631-03-8 3-nitro-N-(2,3-dimethylphenyl)benzamide 

Downstream Products

• 183270-20-4 3-[2(R)-(t-butyloxycarbonylamino)-3-(triphenylmethyl-mercapto)propylamino ]-N-(2, 3-dimethylphenyl)benzamide 

Relevant articles and documents

Design, synthesis and early structure-activity relationship of farnesyltransferase inhibitors which mimic both the peptidic and the prenylic substrate

Inhibition of the farnesylation of ras proteins has been identified as a promising target in tumor therapy. Only a few farnesyltransferase inhibitors are bisubstrate analogues displaying features of both substrates, the farnesylpyrophosphate and the C-terminal CAAX-tetrapeptide sequence of the ras protein. These known bisubstrate analogues consist of an AAX-tripeptide and a farnesyl residue connected through various linkers. We have developed a class of novel compounds that mimic a bisubstrate inhibitor structure and that differ from the known ones by lacking peptidic or farnesylic substructures. Long chain fatty acids and aryl-substituted carboxylic acids were used as farnesyl surrogates. These structures were linked to isoleucine amide, benzoic acid amide, N-substituted aminobenzenesulfonamides and N(α)-aryl-substituted methionine derivatives, respectively, which function as AA- or AAX-mimetics. Copyright (C) 2000 Elsevier Science Ltd.

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention comprises peptidomimetic compounds which comprise a suitably aniline and aminoalkylbenzene moieties. The instant compounds inhibit the farnesyl-protein transferase enzyme and the farnesylation of certain proteins. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.