1026322-46-2

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 176963-27-2 2-(3,4-Dimethoxy-phenyl)-1-ethyl-6-methoxy-7-methoxymethoxy-3-methyl-1H-indole 
• 1027904-07-9 2-(3,4-Dimethoxy-phenyl)-6-methoxy-7-methoxymethoxy-1H-indole-3-carbaldehyde 
• 176963-21-6 3,4-Dimethoxy-N-(3-methoxy-2-methoxymethoxy-6-methyl-phenyl)-benzamide 
• 176963-24-9 2-(3,4-Dimethoxy-phenyl)-6-methoxy-7-methoxymethoxy-1H-indole 
• 176963-19-2 3-methoxy-2-(methoxymethoxy)-6-methylaniline 
• 111726-42-2 1-methoxy-2-(methoxymethoxy)-4-methylbenzene 

Downstream Products

• 1026876-35-6 (E)-3-[2-(3,4-Dimethoxy-phenyl)-1-ethyl-6-methoxy-7-methoxymethoxy-3-methyl-1H-indol-4-yl]-2-methyl-acrylic acid 
• 1026752-21-5 (E)-3-[2-(3,4-Dimethoxy-phenyl)-1-ethyl-6-methoxy-7-methoxymethoxy-3-methyl-1H-indol-4-yl]-2-methyl-acrylic acid ethyl ester 

Relevant academic research and scientific papers

Hydroxyindole derivatives as inhibitors of IL-1 generation. II. Synthesis and pharmacological activities of (E)3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives

A series of (E)-3-(7-hydroxy-6-methoxyindole-4-yl)-2-methylpropenoic acid derivatives was prepared and the inhibitory activities of its members on IL-1 generation were evaluated in an in vitro system using exudate cells from the rat carboxy-methyl cellulose (CMC) induced air-pouch model. All the compounds in this new series were found to be inhibitors of IL-1 generation. In particular, the methoxy-substituted 2-phenyl compounds 28d-f were the most potent inhibitors of IL-1 generation (eg, 28d: IC50 = 0.8 μ,M). The compounds in this series also inhibited IL-1α and IL-1β generations in an in vitro system using human monocytes stimulated with LPS (eg, 28b: IC50 = 1.4 μM (IL-1α) and 0.9 μM (IL-1β)).