1026348-21-9

Upstream product

• 89-99-6 2-fluorobenzylamine 
• 342816-77-7 {3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)-ethylamino]-2-oxo-2H-pyrazin-1-yl}acetic acid 
• 435345-04-3 2,2-difluoro-2-(2-pyridyl)ethylamine benzenesulfonic acid salt 
• 613258-75-6 ethyl [2-oxo-3-(pyridin-2-ylthio)pyrazin-1(2H)-yl]acetate 
• 435345-05-4 ethyl 2-(3-chloro-2-oxopyrazin-1(2H)-yl)acetate 
• 342816-01-7 {3-[2,2-difluoro-2-(1-oxy-pyridin-2-yl)ethylamino]-2-oxo-2H-pyrazin-1-yl}acetic acid ethyl ester 
• 312904-87-3 ethyl 3-hydroxypyrazin-(1H)-2-one-1-acetate 
• 267876-34-6 ethyl 2-[3-bromo-2-oxo-1(2H)-pyrazinyl]acetate 
• 342816-00-6 2,2-difluoro-2-(1-oxido-2-pyridintl)ethylamine 

Downstream Products

• 342815-51-4 N-2-fluorobenzyl [3-(2,2-difluoro-2-(2-pyridyl-N-oxide)ethylN-amino)-6-chloro-2-oxo-2H-pyrazin-1-yl]acetamide 

Relevant academic research and scientific papers

Synthesis of 3-Aminopyrazinone Mediated by 2-Pyridylthioimidate-ZnCl 2 Complexes. Development of an Efficient Route to a Thrombin Inhibitor

A six-step preparation of thrombin inhibitor drug candidate 1 from pyrazinone 7 in 47% overall yield is described. The problem of low reactivity between weak amine nucleophile 4 and poor electrophile 3-bromopyrazinone 17 was overcome with the use of pyrid