1026350-55-9

Basic information

• Product Name: 5-fluoro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide
• Synonyms: 5-fluoro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide
• CAS NO: 1026350-55-9
• Molecular Weight: 418.273
• Mol File: 1026350-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-fluoro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide(1026350-55-9)
• EPA Substance Registry System: 5-fluoro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide(1026350-55-9)

Safety Data

• Hazardous Substances Data: 1026350-55-9(Hazardous Substances Data)

Upstream product

• 402-66-4 5-fluoropyridine-3-carboxylic acid 
• 123066-64-8 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline 

Relevant articles and documents

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC50 = 77 nM) and exhibited high selectivity for the CRAC channel over the VOC channel (index: >130). Another acted as an inhibitor for both T lymphocyte activation-induced diseases and ovalbumin-induced airway eosinophilia in rats (ED50 = 1.3 mg/kg) p.o.