102638-45-9 Usage
General Description
Tert-butyl 3-(aminomethyl)benzoate is a chemical compound with the molecular formula C13H19NO2. It is a derivative of benzoic acid and contains a tert-butyl group and an aminomethyl group. tert-butyl 3-(aminomethyl)benzoate is commonly used in the production of pharmaceuticals and as a chemical intermediate in organic synthesis. It has potential applications in the development of medications and other bioactive compounds due to its unique molecular structure. Tert-butyl 3-(aminomethyl)benzoate may also be used in research and development projects in the pharmaceutical and biotechnology industries. Its properties and reactivity make it a valuable compound for various chemical and pharmaceutical uses.
Check Digit Verification of cas no
The CAS Registry Mumber 102638-45-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,6,3 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 102638-45:
(8*1)+(7*0)+(6*2)+(5*6)+(4*3)+(3*8)+(2*4)+(1*5)=99
99 % 10 = 9
So 102638-45-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO2/c1-12(2,3)15-11(14)10-6-4-5-9(7-10)8-13/h4-7H,8,13H2,1-3H3
102638-45-9Relevant articles and documents
Structural optimization and structure–activity relationship of 4-thiazolidinone derivatives as novel inhibitors of human dihydroorotate dehydrogenase
Zeng, Fanxun,Quan, Lina,Yang, Guantian,Qi, Tiantian,Zhang, Letian,Li, Shiliang,Li, Honglin,Zhu, Lili,Xu, Xiaoyong
, (2019/08/07)
Human dihydroorotate dehydrogenase (hDHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising hDHODH inhibitors is in high demand. Based on the unique binding mode of our previous reported 4-thiazolidinone derivatives, via molecular docking method, three new series 4-thiazolidinone derivatives were designed and synthesized as hDHODH inhibitors. The preliminary structure–activity relationship was investigated. Compound 9 of biphenyl series and compound 37 of amide series displayed IC50 values of 1.32 μM and 1.45 μM, respectively. This research will provide valuable reference for the research of new structures of hDHODH inhibitors.
