102638-71-1

Basic information

• Product Name: L-Phenylalaninamide, L-isoleucyl-
• CAS NO: 102638-71-1
• Molecular Formula: C15H23N3O2
• Molecular Weight: 277.367
• Mol File: 102638-71-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Phenylalaninamide, L-isoleucyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalaninamide, L-isoleucyl-(102638-71-1)
• EPA Substance Registry System: L-Phenylalaninamide, L-isoleucyl-(102638-71-1)

Safety Data

• Hazardous Substances Data: 102638-71-1(Hazardous Substances Data)

Upstream product

• 120636-88-6 [1-(1-carbamoyl-2-phenylethylcarbamoyl)-2-methylbutyl]carbamic acid tert-butyl ester 
• 5241-58-7 L-Phenylalanine amide 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 13139-16-7 N-tert-butyloxy-isoleucine 
• 3392-08-3 tert-(butoxycarbonyl)isoleucine succinimidyl ester 
• 120636-88-6 [(S)-1-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-butyl]-carbamic acid tert-butyl ester 

Downstream Products

• 1138243-24-9 bis(Boc-Cys-Ile-Phe-NH₂) 
• 126409-58-3 {(1S,2S,4R)-1-Benzyl-4-[(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-phenyl-pentyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Sidechain-linked inhibitors of HIV-1 protease dimerization

There is a great need for alternative modes of inhibition for the design of anti-HIV therapies, due to the increased resistance of HIV to currently approved drugs. A novel strategy for generating potent dimerization inhibitors of HIV-1 protease is describ

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679

A series of tetrapeptide analogues of 1 (L-682,679), in which the carboxy terminus has been shortened and modified, was prepared and their inhibitory activity measured against the HIV protease in a peptide cleavage assay. Selected examples were tested as inhibitors of virus spread in cell culture. Compound 12 was a 10-fold more potent enzyme inhibitor than 1 in vitro and 30-fold more potent in inhibiting the viral spread in cells.