1026381-75-8Relevant academic research and scientific papers
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6- aminopyrimidine inhibitors of cyclin-dependent kinase 2
Marchetti, Francesco,Sayle, Kerry L.,Bentley, Johanne,Clegg, William,Curtin, Nicola J.,Endicott, Jane A.,Golding, Bernard T.,Griffin, Roger J.,Haggerty, Karen,Harrington, Ross W.,Mesguiche, Veronique,Newell, David R.,Noble, Martin E. M.,Parsons, Rachel J.,Pratt, David J.,Wang, Lan Z.,Hardcastle, Ian R.
, p. 1577 - 1585 (2008/02/04)
An efficient synthesis of 2-substituted O4-cyclohexylmethyl-5- nitroso-6-aminopyrimidines from 6-amino-2-mercaptopyrimidin-4-ol has been developed and used to prepare a range of derivatives for evaluation as inhibitors of cyclin-dependent kinas
