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10264-75-2

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10264-75-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 10264-75-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,2,6 and 4 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10264-75:
(7*1)+(6*0)+(5*2)+(4*6)+(3*4)+(2*7)+(1*5)=72
72 % 10 = 2
So 10264-75-2 is a valid CAS Registry Number.

10264-75-2Relevant articles and documents

Discovery and structure-activity relationship study of phthalimide-phenylpyridine conjugate as inhibitor of Wnt pathway

Wu, Hongna,Wu, Jun,Zhang, Wenxuan,Li, Zhongwen,Fang, Jinhui,Lian, Xu,Qin, Tong,Hao, Jie,Zhou, Qi,Wu, Song

, p. 870 - 872 (2019)

Aberrant Wnt signaling has been implicated in a variety of disease. Inhibition of the Wnt pathway is an attractive approach for developing new therapeutics for the treatment of various types of fibrosis and cancers. We have discovered the phthalimide-phenylpyridine conjugate as a novel hit compound for the Wnt pathway inhibitors from cellular screening. The structure-activity relationship of these compounds suggested both of the substituent group on the phthalimide fragment and the structure of the linker were critical to the inhibitory activity. The most potent compound was about 10-folds more potent than the hit compound, with IC50 value of 0.28 ± 0.01 μM.

Amide compounds for regulating WNT signal channel and application of compounds

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Paragraph 0192; 0194, (2019/07/11)

The invention belongs to the technical field of medicine, and particularly relates to amide compounds for regulating a WNT signal channel and an application of the compounds. The compounds have a structure represented by a general formula I shown in the description.

Protecting-group-based colorimetric monitoring of fluorous-phase and solid-phase synthesis of oligoglucosamines

Ko, Kwang-Seuk,Park, Gisun,Yu, Yang,Pohl, Nicola L.

supporting information; experimental part, p. 5381 - 5384 (2009/06/18)

(Chemical Equation Presented) A new hydroxyl protecting group, nitrophthalimidobutyric (NPB) acid, has been synthesized in one solvent-free step for colorimetric monitoring of reaction cycles upon its facile removal with hydrazine acetate in the solid-pha

Method of inhibiting binding of nerve growth factor to p75 NTR receptor

-

, (2008/06/13)

The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTRcommon neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTRcomprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101and Phe86of nerve growth factor.

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