10264-75-2Relevant articles and documents
Discovery and structure-activity relationship study of phthalimide-phenylpyridine conjugate as inhibitor of Wnt pathway
Wu, Hongna,Wu, Jun,Zhang, Wenxuan,Li, Zhongwen,Fang, Jinhui,Lian, Xu,Qin, Tong,Hao, Jie,Zhou, Qi,Wu, Song
, p. 870 - 872 (2019)
Aberrant Wnt signaling has been implicated in a variety of disease. Inhibition of the Wnt pathway is an attractive approach for developing new therapeutics for the treatment of various types of fibrosis and cancers. We have discovered the phthalimide-phenylpyridine conjugate as a novel hit compound for the Wnt pathway inhibitors from cellular screening. The structure-activity relationship of these compounds suggested both of the substituent group on the phthalimide fragment and the structure of the linker were critical to the inhibitory activity. The most potent compound was about 10-folds more potent than the hit compound, with IC50 value of 0.28 ± 0.01 μM.
Protecting-group-based colorimetric monitoring of fluorous-phase and solid-phase synthesis of oligoglucosamines
Ko, Kwang-Seuk,Park, Gisun,Yu, Yang,Pohl, Nicola L.
supporting information; experimental part, p. 5381 - 5384 (2009/06/18)
(Chemical Equation Presented) A new hydroxyl protecting group, nitrophthalimidobutyric (NPB) acid, has been synthesized in one solvent-free step for colorimetric monitoring of reaction cycles upon its facile removal with hydrazine acetate in the solid-pha
