1026439-30-4Relevant academic research and scientific papers
Potent dual thymidylate synthase and dihydrofolate reductase inhibitors: Classical and nonclassical 2-amino-4-oxo-5-arylthio-substituted-6- methylthieno[2,3-d]pyrimidine antifolates
Gangjee, Aleem,Qiu, Yibin,Li, Wei,Kisliuk, Roy L.
experimental part, p. 5789 - 5797 (2009/09/25)
N-{4-[(2-Amino-6-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl) sulfanyl]benzoyl}-L-glutamic acid (4) and nine nonclassical analogues 5-13 were synthesized as potential dual thymidylate synthase (TS) and dihydrofolate reductase (DHFR) inhibitors. Th
