1026512-97-9

Basic information

• Product Name: 2-hydroxy-3,3-diphenyl-3-(2-p-tolyl-ethoxy)-propionic acid methyl ester
• Synonyms: 2-hydroxy-3,3-diphenyl-3-(2-p-tolyl-ethoxy)-propionic acid methyl ester
• CAS NO: 1026512-97-9
• Molecular Weight: 390.479
• Mol File: 1026512-97-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-3,3-diphenyl-3-(2-p-tolyl-ethoxy)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3,3-diphenyl-3-(2-p-tolyl-ethoxy)-propionic acid methyl ester(1026512-97-9)
• EPA Substance Registry System: 2-hydroxy-3,3-diphenyl-3-(2-p-tolyl-ethoxy)-propionic acid methyl ester(1026512-97-9)

Safety Data

• Hazardous Substances Data: 1026512-97-9(Hazardous Substances Data)

Upstream product

• 699-02-5 4-Methylphenethyl alcohol 
• 76527-25-8 3,3-diphenyloxirane-2-carboxylic acid methyl ester 

Downstream Products

• 1027463-97-3 2-hydroxy-3,3-diphenyl-3-(2-p-tolyl-ethoxy)-propionic acid 

Relevant articles and documents

Discovery and synthesis of (S)-3-[2-(3,4-dimethoxyphenyl)ethoxy]-2(4,6- dimethylpyrimidin-2-yloxy)-3,3-diphenylpropionic acid (LU 302872), a novel orally active mixed ET(A)/ET(B) receptor antagonist

Structural variation of the endothelin A-selective antagonist (S)-3- methoxy-2-(4,6-dimethoxy-pyrimidin-2-yloxy)-3,3-diphenylpropionic acid (LU 135252) led to analogues which retain ETA affinity but exhibit substantial ET(B) affinity as well. The most active derivative obtained is (S)-3-[2- (3,4-dimethoxyphenyl)ethoxy]-2-(4,6-dimethylpyrimidin-2-yloxy)-3,3- diphenylpropionic acid (LU 302872), which can be prepared in enantiomerically pure form in eight steps via an acid-catalyzed transetherification. It has a K(i) = 2.15 nM for binding to the ETA receptor and a K(i) = 4.75 nM for binding to the ET(B) receptor, is orally available, and antagonizes the big ET-induced blood pressure increase in rats and the big ET-induced bronchospasm in guinea pigs each time at a dose of 10 mg/kg.