102652-49-3Relevant academic research and scientific papers
A modular, efficient, and stereoselective synthesis of substituted piperidin-4-ols
Cui, Li,Li, Chaoqun,Zhang, Liming
supporting information; experimental part, p. 9178 - 9181 (2011/02/28)
The pied piper-idinol of Hamelin: The one-pot synthesis of piperidin-4-ols by sequential gold-catalyzed cyclization, chemoselective reduction, and spontaneous Ferrier rearrangement has a broad substrate scope and shows excellent diastereoselectivity in th
Stereoselective intramolecular nitrone cycloaddition in the synthesis of Lasubine II.
Hoffmann, Reinhard W.,Endesfelder, Andreas
, p. 1823 - 1836 (2007/10/02)
The intramolecular cycloaddition of α-substituted N-alkenylnitrones 2 leads to the 7-oxa-1-azanorbornanes 6,7, and 8 with a selectivity of ca. 80percent in favor of the exo,exo-disubstituted compound 6.The latter can be reduced to give the all-cis-2,6-disubstituted 4-hydroxypiperidines 4 which are key compounds for the synthesis of certain alkaloids as demonstrated by the synthesis of lasubine II.
