1026561-51-2

Basic information

• Product Name: ethyl (Z)-2-fluoro-4-isopropoxy-3,4-diphenylbut-2-enoate
• CAS NO: 1026561-51-2
• Molecular Weight: 342.41
• Mol File: 1026561-51-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (Z)-2-fluoro-4-isopropoxy-3,4-diphenylbut-2-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (Z)-2-fluoro-4-isopropoxy-3,4-diphenylbut-2-enoate(1026561-51-2)
• EPA Substance Registry System: ethyl (Z)-2-fluoro-4-isopropoxy-3,4-diphenylbut-2-enoate(1026561-51-2)

Safety Data

• Hazardous Substances Data: 1026561-51-2(Hazardous Substances Data)

Upstream product

• 2356-16-3 ethyl(diethylphosphono)(fluoro)acetate 
• 6652-28-4 benzoin isopropyl ether 

Relevant articles and documents

Convenient synthesis of 3-fluoro-4,5-diphenylfuran-2(5H)-one from benzoin ethers. Novel and efficient Z-E isomerisation and cyclisation of 2-fluoroalkenoate precursors, substitution of vinylic fluorine

Mixtures of ethyl (E)- and (Z)-4-alkoxy-2-fluoro-3,4-diphenylbut-2-enoates (6-8) prepared from benzoin ethers and ethyl 2-(diethoxyphosphoryl)-2-fluoroacetate were transformed in high yields to the target 3-fluoro-4,5-diphenylfuran-2(5H)-one (14) using bromine in tetrachloromethane at room temperature. The non-cyclisable Z-isomers 6b-8b were gradually isomerised to the cyclisable E-isomers 6a-8a during the process. The reaction of the (E)-butenoates 6a-8a with boron trifluoride led to furanone 14, while in Z-isomers 6b-8b both alkoxy group and vinylic fluorine were substituted with bromine during the reaction. Mechanisms for both complex reactions have been proposed. Furanone 14 was transformed to 2-[tert-butyl(dimethyl)silyloxy]-3-fluoro-4,5-diphenylfuran (18) as a novel building block.