1026591-00-3

Upstream product

• 1073-69-4 N-4-chlorophenylhydrazine 
• 127107-00-0 ethyl 2-amino-3-methoxycarbonyl-4-oxo-2-pentanoate 
• 268544-84-9 ethyl 1-(4-chlorophenyl)-4-(methoxycarbonyl)-5-methyl-3-pyrazolecarboxylate 
• 268544-89-4 1-(4-chlorophenyl)-1-(4-methoxycarbonyl)-5-methyl-1H-pyrazole-3-carboxylic acid 

Downstream Products

• 268544-94-1 methyl 3-tert-butylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate 
• 268544-99-6 methyl 3-cyclopropylcarboxamido-1-(4-chlorophenyl)-5-methyl-4-pyrazolecarboxylate 

Relevant academic research and scientific papers

A new synthetic entry to 3-carboxamido-4-carboxylic acid derivatives of isoxazole and pyrazole

Ethyl 2-amino-3-methoxycarbonyl-4-oxo-2-pentenoate (3) reacts with hydroxylamine or hydrazines to give isoxazole and pyrazole ortho-dicarboxylic acid esters 4 and 5, respectively. Partial hydrolysis of diesters 4 and 5 afforded the corresponding dicarboxy